USP7 Human shRNA Plasmid Kit (Locus ID 7874)
SKU
TL308454
USP7 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 7874 |
|---|---|
| Synonyms | HAFOUS; HAUSP; TEF1 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | USP7 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 7874). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001286457, NM_001286458, NM_003470, NM_001321858, NR_135826, NM_003470.1, NM_001286458.1, NM_001286457.1, BC166690, BM661563, NM_001286458.2, NM_003470.3 |
| UniProt ID | Q93009 |
| Summary | The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. provided by RefSeq, Mar 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation
Vega, Chen, Shi et al
J Biol Chem (2022) 298 (4), 101750 DOI: 10.1016/j.jbc.2022.101750
Vega, Chen, Shi et al
J Biol Chem (2022) 298 (4), 101750 DOI: 10.1016/j.jbc.2022.101750
Cited by 8
AI Summary: OriGene contributed to this study by providing lentivirus-expressing shRNAs targeting USP-7 (catalog no.: TL308454V), which were used to investigate the role of USP-7 in DEPTOR stability in multiple myeloma cells.
Snippet: ines were obtained from American Type Culture Collection. They were tested for mycoplasma within the last 6 months and were negative. Lentivirus-expressing shRNAs targeting USP-7 were purchased from Origene (catalog no.: TL308454V). The anti-USP-7 drug, P5091, was obtained from Abcam. The ERK inhibitors U0126 and PD98059 were obtained from Millipore Sigma–Aldrich. The phosphospecific antibody r
Showing 1-1 of 1 papers.
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