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MAVS Human shRNA Plasmid Kit (Locus ID 57506)

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SKU
TL307181
MAVS - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "MAVS or NM_001206491"

Specifications
Specifications
Product Data
Locus ID 57506
Synonyms CARDIF; IPS-1; IPS1; VISA
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components MAVS - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 57506). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001206491, NM_020746, NR_037921, NR_037922, NM_020746.1, NM_020746.2, NM_020746.3, NM_020746.4, NM_001206491.1, BC044952, BC044952.1, BC000073, BC040719, BC040930, BC052583, BC062310, BC063593, BM834250, NM_020746.5
UniProt ID Q7Z434
Summary This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral innate immunity. provided by RefSeq, Jul 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The role of chromatin remodeling in H3K27M-mutant gliomas
Krug
Thesis (2022)
Snippet: MAVS Knockdown. MAVS Human shRNA lentiviral particles (TL307181V) were purchased from OriGene. A pool of four shRNAs targeting MAVS were transduced into cell lines at a concentration of 2 TU/cell, alongside a scramble control shRNA particle (sh-NT). … Loss of MAVS protein was confirmed by western
Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas
Krug, De Jay, Harutyunyan et al
Cancer Cell (2019) 35 (5), 782-797.e8 DOI: 10.1016/j.ccell.2019.04.004
AI Summary: OriGene’s MAVS Human shRNA lentiviral particles (Cat# TL307181V) were used in this study to manipulate MAVS expression, enabling the investigation of molecular mechanisms underlying ERV expression and therapeutic vulnerabilities in H3K27M gliomas.
Snippet: MAVS Human shRNA lentiviral particles (Locus ID 57506) OriGene Cat# TL307181V H3K27M lentiviral particles VectorBuilder Cat# VB171024-1031kuk
Figure
Showing 1-2 of 2 papers.
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