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ADAM12 Human shRNA Plasmid Kit (Locus ID 8038)

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SKU
TL306850
ADAM12 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "ADAM12 or NM_001288973"

Specifications
Specifications
Product Data
Locus ID 8038
Synonyms ADAM12-OT1; CAR10; MCMP; MCMPMltna; MLTN; MLTNA
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components ADAM12 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 8038). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001288973, NM_001288974, NM_001288975, NM_003474, NM_021641, NM_003474.1, NM_003474.3, NM_003474.4, NM_003474.5, NM_021641.1, NM_021641.2, NM_021641.3, NM_021641.4, NM_001288975.1, NM_001288974.1, NM_001288973.1, BC060804, NM_001288975.2, NM_001288974.2, NM_021641.5, NM_001288973.2
UniProt ID O43184
Summary This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. provided by RefSeq, Jan 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial‑mesenchymal transition
Oh, Park, Park et al
Int J Oncol (2023) 62 (4) DOI: 10.3892/ijo.2023.5498
Cited by 5
AI Summary: OriGene products, specifically the ADAM12-pGFP-C-shLenti shRNA construct (cat. no. TL306850), were used in this study to knock down ADAM12 expression, enabling the researchers to investigate the role of ADAM12 in promoting epithelial-mesenchymal transition and metastasis in colorectal cancer.
Snippet: sion. Empty-pcDNA6-myc vector was used as a negative control of ADAM12 overexpression. Knockdown of ADAM12 was carried out using ADAM12-pGFP-C-shLenti short hairpin RNA constructs (cat. no. TL306850;Origene Technologies, Inc.) and ADAM12-small interfering (si)RNA duplex (5′-GAC UAC AAC GGG AAA GCA A-3′;Bioneer). Scrambled siRNA (AllStars Negative Control siRNA;cat. no. 1027281) and scramble
FigureFigureFigure
A Disintegrin and Metalloprotease 12 Promotes Tumor Progression by Inhibiting Apoptosis in Human Colorectal Cancer
Park, Park, Oh et al
Cancers (Basel) (2021) 13 (8) DOI: 10.3390/cancers13081927
Cited by 19
AI Summary: OriGene products, specifically the ADAM12-pcDNA6-myc (overexpression plasmid) and ADAM12-pGFP-C-shLenti (shRNA knockdown lentiviral plasmid), were used in this study to manipulate ADAM12 expression in colorectal cancer cells and xenograft models, enabling the authors to demonstrate ADAM12’s role in promoting tumor progression and inhibiting apoptosis.
FigureFigureFigure
Showing 1-2 of 2 papers.
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