Caspase 8 (CASP8) Human shRNA Plasmid Kit (Locus ID 841)
SKU
TL305635
CASP8 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 841 |
|---|---|
| Synonyms | ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | CASP8 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 841). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001080124, NM_001080125, NM_001228, NM_033355, NM_033356, NM_033357, NM_033358, NR_111983, NM_033356.1, NM_033356.2, NM_033356.3, NM_001080125.1, NM_033355.1, NM_033355.2, NM_033355.3, NM_033358.2, NM_033358.3, NM_001080124.1, NM_001228.1, NM_001228.2, NM_001228.3, NM_001228.4, BC010390, BC017031, BC028223, BC068050, NM_001080125.2, NM_033358.4, NM_033356.4, NM_001080124.2 |
| UniProt ID | Q14790 |
| Summary | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. provided by RefSeq, Jul 2008 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
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