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DNMT3A Human shRNA Plasmid Kit (Locus ID 1788)

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SKU
TL304938
DNMT3A - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 1788
Synonyms DNMT3A2; HESJAS; M.HsaIIIA; TBRS
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components DNMT3A - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 1788). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001320892, NM_001320893, NM_022552, NM_153759, NM_175629, NM_175630, NR_135490, NM_175629.1, NM_175629.2, NM_022552.1, NM_022552.2, NM_022552.3, NM_022552.4, NM_153759.1, NM_153759.2, NM_153759.3, NM_175630.1, BC043617, BC043617.1, BC018214, BC023612, BC032392, BC051864, BM470515, NM_022552.5
UniProt ID Q9Y6K1
Summary CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. provided by RefSeq, Mar 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The Otto Aufranc Award: DNMT3A-PPARγ Signaling Is a Key Epigenetic Mechanism of Hip Osteoarthritis Disease: A Potential Therapeutic Target
Kikuchi, Shen, Brophy et al
J Arthroplasty (2025) 40 (8S1), S9-S16 DOI: 10.1016/j.arth.2025.03.079
Cited by 4
AI Summary: OriGene products—specifically the DNMT3A overexpression plasmid (cat# RC208192L4), DNMT3A suppression plasmid (cat# TL304938), and scrambled control plasmid (cat# TR30021)—were used to generate lentiviral particles for manipulating DNMT3A expression in chondrocytes, enabling the study of its role in hip osteoarthritis progression.
Snippet: ntiviral plasmids (OriGene, cat# RC208192L4 for DNMT3A overexpression, cat# TL304938 for suppression, and cat# TR30021 for scrambled control) were used to produce corresponding lentivirus (LV) particles by Hope Center Core at Washington University in St. Louis using the calcium phosphate precipit
Epigenetic regulation of CXCL12 plays a critical role in mediating tumor progression and the immune response in osteosarcoma
Li, Wang, Wu et al
Cancer Res. (2018)
AI Summary: OriGene products, including lentiviral shRNAs for DNMT1, DNMT3a, CXCR4 (#TL514641, #TL313404, #TL500549, #TL304938, #TL500383, #TL313630) and a CXCR4 overexpression construct (#RC202069), were used to manipulate gene expression and investigate the roles of these genes in CXCL12 regulation and tumor progression in osteosarcoma.
Snippet: Knockdown of homo or 126 mouse DNMT1, DNMT3a, CXCR4, and overexpression of CXCR4 was achieved using lentiviral 127 shRNAs (#TL514641, #TL313404, #TL500549, #TL304938, #TL500383, #TL313630, and #RC202069, 128 OriGene)
Showing 1-2 of 2 papers.
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