LARGE2 Human shRNA Plasmid Kit (Locus ID 120071)
Specifications
| Product Data | |
| Locus ID | 120071 |
|---|---|
| Synonyms | GYLTL1B; PP5656 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | LARGE2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 120071). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001300721, NM_001300722, NM_152312, NM_152312.1, NM_152312.2, NM_152312.3, NM_152312.4, NM_001300722.1, BC037291, BC037291.2, BM840813, NM_001300722.2, NM_152312.5 |
| UniProt ID | Q8N3Y3 |
| Summary | Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units -3-Xylose-alpha-1,3-GlcA-beta-1- to produce a heteropolysaccharide. Has a higher activity toward alpha-dystroglycan than LARGE.UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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