PHLPP (PHLPP1) Human shRNA Plasmid Kit (Locus ID 23239)

SKU
TL302501
PHLPP1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*
Specifications
Specifications
Product Data
Locus ID 23239
Synonyms PHLPP; PLEKHE1; PPM3A; SCOP
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components PHLPP1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 23239). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_194449, NM_194449.1, NM_194449.2, NM_194449.3, BC014927, BC014927.2, BC010706, BC047653, BC063519, BC082244, BC126277
UniProt ID O60346
Summary This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. provided by RefSeq, Dec 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Oncogenic suppression of PHLPP1 in human melanoma
Dong, Jin, Tseng et al
Oncogene (2013)
Cited by 38
AI Summary: OriGene's Human PHLPP1 shRNA kit (TG302501) and scramble shRNA kit (TG300130) were used in this study to specifically knock down PHLPP1 expression, enabling the researchers to investigate its role in Akt activation and melanoma progression.
Snippet: The siRNA constructs for PHLPP1 and Sp1 were obtained from Shanghai GenePharma Co., Ltd (Shanghai, China). Human PHLPP1 shRNA kit (TG302501) and scramble shRNA kit (TG300130) were purchased from Origene (Karrinyup, WA, Australia)
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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