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RAD17 Human shRNA Plasmid Kit (Locus ID 5884)

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SKU
TL302133
RAD17 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "RAD17 or NM_001278622"

Specifications
Specifications
Product Data
Locus ID 5884
Synonyms CCYC; HRAD17; R24L; RAD17SP; RAD24
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components RAD17 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 5884). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001278622, NM_002873, NM_133338, NM_133339, NM_133340, NM_133341, NM_133342, NM_133343, NM_133344, NM_002873.1, NM_133340.1, NM_133340.2, NM_133343.1, NM_133344.1, NM_133344.2, NM_133342.1, NM_133342.2, NM_133339.1, NM_133339.2, NM_133341.1, NM_133341.2, NM_133338.1, NM_133338.2, NM_001278622.1, BC032304, BC032304.1, BC018110, NM_133338.3, NM_133344.3, NM_133342.3
UniProt ID O75943
Summary The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. provided by RefSeq, Jul 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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