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SMG7 Human shRNA Plasmid Kit (Locus ID 9887)

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TL301497
SMG7 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
4 Weeks*

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Specifications
Specifications
Product Data
Locus ID 9887
Synonyms C1orf16; EST1C; SGA56M
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Format Lentiviral plasmids
Components SMG7 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 9887). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001174061, NM_014837, NM_173156, NM_201568, NM_201569, NM_001331007, NM_001350219, NM_001350220, NM_001350221, NM_001350222, NM_173156.1, NM_173156.2, NM_201568.1, NM_201568.2, NM_201569.1, NM_201569.2, NM_001174061.1, NM_014837.1, BC009281, BC015788, BC036381, BC052565, BM152501, NM_201568.3, NM_201569.3, NM_001174061.2, NM_173156.3
UniProt ID Q92540
Summary This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. provided by RefSeq, Aug 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.