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Pdk1 Mouse shRNA Plasmid (Locus ID 228026)

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SKU
TG517458
Pdk1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 228026
Synonyms B830012B01; D530020C15Rik
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Pdk1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 228026). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC027196, NM_172665, NM_001360002, NM_172665.1, NM_172665.2, NM_172665.3, NM_172665.4, NM_172665.5, BC025480
UniProt ID Q8BFP9
Summary Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid β and other toxins by decreasing mitochondrial respiration and reactive oxygen species production
Newington, Rappon, Albers et al
J. Biol. Chem. (2012) 287 (44), 37245-58 DOI: 10.1074/jbc.M112.366195
Cited by 6
AI Summary: OriGene products contributed to this study by providing the human PDK1 (pCMV6-AC) and LDHA (pCMV6-XL4) cDNA expression vectors, which were used to overexpress these enzymes in nerve cells to investigate their role in resistance to amyloid β and other toxins.
Snippet: accumulation likely had undiagnosed mild cognitive impairment and would have eventually developed AD had they lived long enough or ... 80% confluency and transfected with vectors containing human PDK1 (pCMV6-AC) or LDHA (pCMV6-XL4) cDNA (Origene, Rockville, MD).
Showing 1-1 of 1 papers.
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