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Nlgn2 Mouse shRNA Plasmid (Locus ID 216856)

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SKU
TG516880
Nlgn2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 216856
Synonyms NL2; NLG2
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Nlgn2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 216856). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_198862, NM_198862.1, NM_198862.2, BC056478, BC156101, BC156963, NM_001364137
UniProt ID Q69ZK9
Summary Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (PubMed:29742426). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility
Heshmati, Aleyasin, Menard et al
Proc Natl Acad Sci U S A (2018) 115 (5), 1111-1116 DOI: 10.1073/pnas.1719014115
Cited by 77
AI Summary: OriGene products contributed to this study by providing the shRNA plasmids (specifically, the OriGene NLGN-2 shRNA, Cat# TL511482) used to selectively knock down NLGN-2 expression in nucleus accumbens neurons, enabling the investigation of cell-type-specific roles of NLGN-2 in stress and depression.
Showing 1-1 of 1 papers.
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