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Traf6 Mouse shRNA Plasmid (Locus ID 22034)

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SKU
TG515356
Traf6 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 22034
Synonyms 2310003F17Rik; AI851288; C630032O20Rik
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Traf6 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 22034). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC060705, NM_001303273, NM_009424, NM_009424.1, NM_009424.2, NM_009424.3, NM_001303273.1
UniProt ID P70196
Summary This gene encodes a member of the TNF receptor associated factor (TRAF) family of adaptor proteins that mediate signaling events from members of the TNF receptor and Toll/IL-1 receptor families to activate transcription factors such as NF-kappa-B and AP-1. The product of this gene is essential for perinatal and postnatal survival. Mice deficient in this protein exhibit osteopetrosis and defective in development of epidermal appendixes, normal B cell differentiation, lymph node organogenesis, interleukin-1 signaling, lipopolysaccharide signaling and neural tube closure. This protein possesses ubiquitin ligase activity. Alternate splicing of this gene results in multiple transcript variants. provided by RefSeq, Dec 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival
Kisiswa, Fernández-Suárez, Sergaki et al
Cell Rep (2018) 24 (4), 1013-1024 DOI: 10.1016/j.celrep.2018.06.098
AI Summary: OriGene products contributed to this study by providing control shRNA and four unique 29-mer shRNA constructs targeting mouse TRAF6 in a retroviral GFP vector plasmid, which were used to manipulate TRAF6 expression and investigate its role in cerebellar granule neuron survival.
Snippet: ;Control shRNA and 4 unique 29-mer shRNA constructs targeting mouse TRAF6 in retroviral GFP vector plasmids were purchased from Origene. Human RIP2 in pC1 vector was obtained from Dr. Moses Chao’s laboratory. Mutations in RIP2 were introduced using QuickChange Site-Directed Mutagenesis Kit (Stratagene, UK) and verified by DNA sequencing
Showing 1-1 of 1 papers.
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