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Nr4a1 Mouse shRNA Plasmid (Locus ID 15370)

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SKU
TG514239
Nr4a1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 15370
Synonyms Gfrp; GFRP1; Hbr-1; Hbr1; Hmr; N10; NGFI-B; NGFIB; NP10; nur77; TIS1; TR3
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Nr4a1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 15370). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC004770, NM_010444, NM_010444.1, NM_010444.2
UniProt ID P12813
Summary Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (PubMed:22427340).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Segala, David, de Medina et al
Nat Commun (2017) 8 (1), 1903 DOI: 10.1038/s41467-017-01948-9
AI Summary: OriGene’s 29 mer shRNA constructs in pRS retroviral vectors targeting Nur77 and NOR1 were used for gene knockdown experiments to investigate the role of these genes in Dendrogenin A-induced lethal autophagy in cancer cells.
Snippet: For the KD of Nur77 and NOR1 in KG1, 29 mer shRNA constructs in pRS retroviral vectors targeting Nur77 and NOR1 were purchased from Origene
FigureFigureFigure
Showing 1-1 of 1 papers.
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