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Notch1 Mouse shRNA Plasmid (Locus ID 18128)

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SKU
TG513589
Notch1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 18128
Synonyms 9930111A19Rik; lin-12; Mis6; N1; Tan1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Notch1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 18128). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_008714, NM_008714.1, NM_008714.2, NM_008714.3, BC010325, BC058427, BC138441, BC138442
UniProt ID Q01705
Summary Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells
Marcel, Sarin
Elife (2016) 5 DOI: 10.7554/eLife.14023
AI Summary: OriGene products contributed to this study by providing shRNA constructs targeting VPS34, ATG7, RBPJ-k, Dll-1, Notch1, and a scrambled control, which were used to investigate the roles of these genes in Notch1-regulated autophagy and T-regulatory cell function.
Snippet: The plasmids pBABE, pBABE-NIC-NLS, pBABE-NIC-NES were gifts and have been described before (Perumalsamy et al., 2010). pBABE-puro-ATG3 was from Addgene (MA, USA). shRNA specific for VPS34, ATG7, RBPJ-k, Dll-1, Notch1 and scrambled control were from Origene
FigureFigureFigure
Macrophage-Derived Delta-like 1 Enhances Interleukin-6 and Matrix Metalloproteinase-3 Production by Fibroblast-Like Synoviocytes in Arthritic Mice
Sekine, Nanki, Yagita
Arthritis & rheumatology (2014)
Cited by 17
AI Summary: OriGene contributed to this study by providing small interfering RNAs (siRNAs) targeting mouse Notch1 and Notch2, which were used to investigate the roles of these genes in fibroblast-like synoviocytes during arthritis.
Snippet: Healthcare). RNA interference. Small interfering RNAs (siRNAs) targeting mouse Notch1 or Notch2 and scrambled negative control siRNA were purchased from OriGene. Each siRNA was transfected into MFS using Metafectene Pro (Biontex Laboratories). ... Cite SaveSaving
Showing 1-2 of 2 papers.
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