Rbpj Mouse shRNA Plasmid (Locus ID 19664)
SKU
TG512813
Rbpj - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 19664 |
|---|---|
| Synonyms | AI843960; CBF1; Igkjrb; Igkrsbp; RBP-J; RBP-J kappa; RBP-Jkappa; RBPjk; Rbpsuh |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Rbpj - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 19664). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | BC051387, NM_001080927, NM_001080928, NM_001277116, NM_009035, NM_001359152, NM_001080927.1, NM_001080927.2, NM_009035.1, NM_009035.3, NM_009035.4, NM_009035.5, NM_001080928.1, NM_001277116.1, BC035299 |
| UniProt ID | P31266 |
| Summary | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations (PubMed:7566092). Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (PubMed:26194095).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells
Marcel, Sarin
Elife (2016) 5 DOI: 10.7554/eLife.14023
Marcel, Sarin
Elife (2016) 5 DOI: 10.7554/eLife.14023
AI Summary: OriGene products contributed to this study by providing shRNA constructs targeting VPS34, ATG7, RBPJ-k, Dll-1, Notch1, and a scrambled control, which were used to investigate the roles of these genes in Notch1-regulated autophagy and T-regulatory cell function.
Snippet: The plasmids pBABE, pBABE-NIC-NLS, pBABE-NIC-NES were gifts and have been described before (Perumalsamy et al., 2010). pBABE-puro-ATG3 was from Addgene (MA, USA). shRNA specific for VPS34, ATG7, RBPJ-k, Dll-1, Notch1 and scrambled control were from Origene
Showing 1-1 of 1 papers.
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