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Mstn Mouse shRNA Plasmid (Locus ID 17700)

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SKU
TG512805
Mstn - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 17700
Synonyms Cmpt; Gdf8
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mstn - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 17700). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC103676, BC103677, BC103678, BC105674, NM_010834, NM_010834.1, NM_010834.2, NM_010834.3
UniProt ID O08689
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. provided by RefSeq, Jul 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice
Sriram, Subramanian, Juvvuna et al
J. Biol. Chem. (2014)
AI Summary: OriGene’s Mstn-specific shRNA expression vector (shMstn) and control vectors (pGFP-V-RS, scrambled shRNA) were used to transiently knock down Myostatin in C2C12 myoblasts, enabling the authors to investigate Myostatin’s role in DNA damage and oxidative stress in diabetic skeletal muscle.
Snippet: Transient transfection of shRNA to knockdown Mstn C2C12 myoblasts were transfected with 4 µg/well of empty vector control (pGFP-V-RS), scrambled shRNA or Mstn-specific shRNA expression vector (shMstn) (OriGene Technologies, Inc.) using Lipofectamine 2000 ... Cite SaveSaving
Pid1 Induces Insulin Resistance in Both Human and Mouse Skeletal Muscle during Obesity
Bonala, McFarlane, Ang et al
Mol. Endocrinol. (2013) 27 (9), 1518-35 DOI: 10.1210/me.2013-1048
Cited by 27
AI Summary: OriGene products, specifically the human PID1 cDNA clone (MG227629) and the pCMV6-Entry empty vector control (MR227629), were used in this study to manipulate PID1 expression in human myoblasts, enabling the authors to investigate the role of PID1 in insulin resistance.
Snippet: the glucose concentration serially at 5-minute intervals using a glucose oxidase-based glucose analyzer (YSI 2300 STATPLUS, YSI Incorporated, Life Sciences, Yellow ... MG227629) and pCMV6-Entry empty vector control (catalog no, MR227629) were purchased from Origene.
Showing 1-2 of 2 papers.
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