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Eif2ak4 Mouse shRNA Plasmid (Locus ID 27103)

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SKU
TG511649
Eif2ak4 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 27103
Synonyms 2610011M03; GCN2; MGCN2
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Eif2ak4 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 27103). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC072637, NM_001177806, NM_013719, NM_001355383, NM_001177806.1, NM_013719.1, NM_013719.2, NM_013719.3, BC023958, BM250244
UniProt ID Q9QZ05
Summary Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:10504407, PubMed:10655230, PubMed:12176355, PubMed:12215525, PubMed:15213227, PubMed:16054071, PubMed:16176978, PubMed:16121183, PubMed:15774759, PubMed:16601681, PubMed:26102367). Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion (PubMed:10655230, PubMed:11106749, PubMed:12176355, PubMed:15213227, PubMed:16176978, PubMed:26102367). Binds uncharged tRNAs (By similarity). Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:16176978, PubMed:26102367). Plays a role in the consolidation of synaptic plasticity, learning as well as formation of long-term memory (PubMed:16121183). Plays a role in neurite outgrowth inhibition (PubMed:23447528). Plays a role in feeding behavior to maintain amino acid homeostasis; contributes to the innate aversion toward diets of imbalanced amino acid composition (PubMed:16054071, PubMed:15774759). Plays a proapoptotic role in response to glucose deprivation (PubMed:20660158). Promotes global cellular protein synthesis repression in response to UV irradiation independently of the stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) and p38 MAPK signaling pathways (PubMed:12176355).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Genetic or Pharmacological Reduction of PERK Enhances Cortical-Dependent Taste Learning
Ounallah-Saad, Sharma, Edry et al
J. Neurosci. (2014) 34 (44), 14624-32 DOI: 10.1523/JNEUROSCI.2117-14.2014
Cited by 1
AI Summary: In this study, OriGene’s shRNA constructs targeting GCN2 were used to genetically reduce GCN2 expression, helping to investigate the role of eIF2α kinases in cortical-dependent taste learning.
Snippet: shRNA constructs directed against PERK/PKR/GCN2 were purchased from Sigma-Aldrich and OriGene (for PERK and PKR shutdown, we used Sigma-Aldrich clones no. ... TRCN 26988, respectively, in pLKO.1-puro-CMVTurboGFP plasmids;for GCN2 we used OriGene ... Cited by 1 Cite SaveSaving
Showing 1-1 of 1 papers.
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