Pkm Mouse shRNA Plasmid (Locus ID 18746)
SKU
TG511241
Pkm2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 18746 |
|---|---|
| Synonyms | AA414905; AL024370; AL024424; Pk-2; Pk-3; Pk3; Pkm2 |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Pkm2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 18746). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | BC016619, BC094663, NM_001253883, NM_011099, NM_011099.1, NM_011099.2, NM_011099.3, NM_001253883.1, NM_011099.4, NM_001253883.2 |
| UniProt ID | P52480 |
| Summary | Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages (PubMed:29996098).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
Colegio, Chu, Szabo et al
Nature (2014)
Colegio, Chu, Szabo et al
Nature (2014)
Cited by 3032
AI Summary: OriGene products contributed to this study by providing shRNA constructs (TR30013, HT122914B, and HT122915A) used for transfection to knock down Pkm2 and as a scrambled control, enabling the investigation of gene function in tumour-associated macrophages.
Snippet: Short hairpin RNA constructs The following short hairpin RNA (shRNA) constructs, cloned into the pGFP-V-RS plasmid, were obtained from OriGene and used for transfection: TR30013 (scrambled control used in Fig. 4f), 5′-GCACTACCAGAGCTAACTCAGATAGTACT-3′;HT122914B (Pkm2 knockdown 1 used in Fig. 4f), 5′-GCCTCCTTCAAGTGCTGCA-3′;and HT122915A (Pkm2 knockdown 2), 5′-CAGCTATTCGAGGAACTCC-3′
Showing 1-1 of 1 papers.
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