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Mmp13 Mouse shRNA Plasmid (Locus ID 17386)

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SKU
TG511095
Mmp13 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 17386
Synonyms Cl; Clg; Mmp; MMP-1; MMP-13; Mmp1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mmp13 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 17386). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC125320, BC125322, NM_008607, NM_008607.1
UniProt ID P33435
Summary This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. provided by RefSeq, Jun 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The transcription factor SPDEF suppresses prostate tumor metastasis
Steffan, Koul, Meacham et al
J. Biol. Chem. (2012) 287 (35), 29968-78 DOI: 10.1074/jbc.M112.379396
Cited by 7
AI Summary: OriGene's TrueClone MMP9 and MMP13 expression plasmids were used to restore MMP9 or MMP13 expression in SPDEF-expressing prostate cancer cells, helping demonstrate that SPDEF suppresses tumor invasion in part by downregulating these genes.
Snippet: The scrambled (Scr) shRNA vector contains four base pair mismatches within the short hairpin sequence to any known human gene, serving as ... A TrueClone MMP9 or MMP13 expression plasmid was purchased from OriGene, and 0.4 μg of DNA was transfected using Effectene
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases
Pivetta, Scapolan, Pecolo et al
Breast Cancer Res. (2011) 13 (5), R105 DOI: 10.1186/bcr3047
Cited by 117
AI Summary: OriGene's HuSH 29-mer shRNA constructs against MMP-13 were used to stably silence MMP-13 expression in MDA-MB-231 breast cancer cells, enabling the authors to demonstrate that MMP-13 knockdown reduced osteoclast differentiation and bone destruction in models of breast cancer bone metastasis.
Snippet: They further demonstrated that down-regulation of MMP-13 with antisense oligonucleotides significantly reduced bone destruction. ... was abrogated by stably transfecting MDA-MB-231 with HuSH 29-mer shRNA constructs against MMP-13 (Origene Technologies, Rockville, MD
FigureFigureFigure
Showing 1-2 of 2 papers.
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