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Srebf2 Mouse shRNA Plasmid (Locus ID 20788)

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SKU
TG510683
Srebf2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 20788
Synonyms AI608257; bHLHd2; lop13; nuc; SREBP-2; SREBP2; SREBP2gc
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Srebf2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 20788). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_033218, NM_033218.1, BC005777, BC014730, BC023333, BC026556, BC038284, BC048071, BC069989, BC167259
UniProt ID Q3U1N2
Summary Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity
Turrell, Kerr, Gao et al
Genes Dev. (2017)
AI Summary: OriGene products, specifically the GFP+ shRNA plasmids targeting Srebf2 (TG510683A-D) and the control nontargeting sequence (TR30013), were used for gene knockdown experiments to investigate the role of Srebf2 in lung tumor cells.
Snippet: For Srebf2 knockdown, cells were transiently transfected with 10 µg of GFP+ shRNA plasmids (TG510683A-D) or control nontargeting sequence (TR30013) from Origene
FigureFigureFigure
Showing 1-1 of 1 papers.
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