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Adamts12 Mouse shRNA Plasmid (Locus ID 239337)

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SKU
TG510190
Adamts12 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 239337
Synonyms ADAMTS-12; AI605170
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Adamts12 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 239337). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_175501, NM_175501.1, NM_175501.2, NM_175501.3, BC151248, BC152338
UniProt ID Q811B3
Summary This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. provided by RefSeq, Jul 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Identification of relevant genetic alterations in cancer using topological data analysis
Rabadán, Mohamedi, Rubin et al
Nat Commun (2020) 11 (1), 3808 DOI: 10.1038/s41467-020-17659-7
Cited by 58
AI Summary: OriGene products contributed to this study by providing the ADAMTS12 cDNA clone (OriGene, Cat# SC119492), which was used to investigate the functional role of ADAMTS12 in lung cancer.
FigureFigureFigure
Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies
Fontanil, Mohamedi, Moncada-Pazos et al
Cell. Physiol. Biochem. (2019) 52 (5), 1003-1016 DOI: 10.33594/000000069
AI Summary: OriGene’s Adamts12 Mouse shRNA Plasmid (Locus ID: 239337) was used in this study to silence the ADAMTS12 gene in SIM-A9 cells, enabling the researchers to investigate the role of ADAMTS12 in neurocan degradation and its potential impact on neuropathies.
Snippet: ADAMTS12 recombinant protein was obtained as described previously [19]. To perform RNAi of the ADAMTS12 gene in SIM-A9 cells, the Adamts12 Mouse shRNA Plasmid (Locus ID: 239337) from OriGene was employed according to the manufacturer's View as HTML
Showing 1-2 of 2 papers.
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