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Lrp6 Mouse shRNA Plasmid (Locus ID 16974)

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SKU
TG509944
Lrp6 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 16974
Synonyms C030016K15Rik; Cd; Gw; ska26; ska; skax26
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Lrp6 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 16974). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC060704, NM_008514, NM_008514.1, NM_008514.2, NM_008514.3, NM_008514.4
UniProt ID O88572
Summary Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis
Raisch, Côté-Biron, Langlois et al
Research Square (2021) 10 (7), 1792 DOI: 10.3390/cells10071792
Cited by 12
AI Summary: OriGene’s pGFP-V-RS Vector, containing a scrambled shRNA cassette, was used as a control in experiments to assess the effects of Lrp6 gene silencing on intestinal epithelial cells.
Snippet: fluorescent protein (GFP) vector targeting the rat Lrp6 gene as previously described 11. … IEC6 BRAFV600E;- fluorescent protein (GFP) vector targeting the rat Lrp6 gene as previously described 11. …
Showing 1-1 of 1 papers.
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