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Ikbkb Mouse shRNA Plasmid (Locus ID 16150)

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SKU
TG509787
Ikbkb - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 16150
Synonyms AI132552; IKK-2; IKK-beta; IKK2; IKKbeta; IKKb
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Ikbkb - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 16150). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC037723, NM_001159774, NM_010546, NM_001159774.1, NM_010546.1, BC004772, BC019210, BC020334
UniProt ID O88351
Summary Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

A constitutively-active IKK-complex at the axon initial segment
König, Watters, Kinsella et al
Brain Res. (2017)
AI Summary: OriGene's IKKβ-directed small-hairpin RNA plasmids (TG509787’A’-‘D’) were used in this study to silence IKKβ expression and assess its role in IKK signaling at the axon initial segment.
Snippet: Skip to main content;Transfections were conducted on Neuro- 2A, PC12 cells or mature 1 cortical neurons using pFlag-IKK-2 (IKK β Addgene #11103), IKK β -directed small- 2 hairpin RNA plasmids that were purchased from Origene (Rockville, MD, USA, 3 TG509787’A’-‘D’) or pAnkG-eGFP (270 kDa;a kind gif t from V. …
Showing 1-1 of 1 papers.
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