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Depdc5 Mouse shRNA Plasmid (Locus ID 277854)

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SKU
TG508165
Depdc5 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 277854
Synonyms AV016528
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Depdc5 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 277854). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC072604, NM_001025426, NM_001170567, NM_177786, NM_001360014, NM_001025426.1, NM_001025426.2, NM_177786.1, NM_177786.2, NM_177786.3, NM_177786.4, NM_001170567.1
UniProt ID P61460
Summary As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons
Iffland, Baybis, Barnes et al
Neurobiol. Dis. (2018) 114, 184-193 DOI: 10.1016/j.nbd.2018.02.013
AI Summary: OriGene products, including DEPDC5 expression plasmid (MR21587, Myc-DDK tag), NPRL3 expression plasmid (MR208964, Myc-DDK tag), mouse DEPDC5 shRNA-plasmid (TG508165, tGFP), and NPRL3 shRNA plasmid (TG501301, tGFP), were used to manipulate gene expression in neural cells to investigate the roles of DEPDC5 and NPRL3 in regulating cell size, filopodial outgrowth, and mTOR localization.
Snippet: expression plasmid (MR21587, Myc-DDK tag), NPRL3 expression plasmid (MR208964;Myc-DDK tag), mouse DEPDC5 shRNA-plasmid (TG508165, tGFP) or NPRL3 shRNA containing plasmid (TG501301, tGFP) were transfected (all plasmids from Origene, Rockville
Showing 1-1 of 1 papers.
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