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Gpbar1 Mouse shRNA Plasmid (Locus ID 227289)

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SKU
TG506766
Gpbar1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 227289
Synonyms BG37; GPCR; GPR131; M-BAR; TGR5
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Gpbar1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 227289). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC116914, BC119327, NM_174985, NM_174985.1
UniProt ID Q80SS6
Summary Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids (By similarity). Involved in bile acid promoted GLP1R secretion.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis
Biagioli, Carino, Cipriani et al
J. Immunol. (2017)
AI Summary: OriGene products—specifically the IL-10 mouse shRNA plasmid (pRFP-C-RS) and GPBAR1 mouse shRNA plasmid (pGFP-V-RS)—were used in this study to suppress IL-10 and GPBAR1 expression, enabling the authors to investigate the functional roles of these genes in macrophage phenotype regulation and colitis.
Snippet: For IL-10 RNA silencing, an IL-10 mouse short hairpin RNA plasmid (pRFP-C-RS) and a GPBAR1 mouse short hairpin RNA plasmid (pGFP-V- RS) were purchased from OriGene Technologies and were used to suppress IL-10 and GPBAR1 expression.
Showing 1-1 of 1 papers.
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