Kdm6b Mouse shRNA Plasmid (Locus ID 216850)
SKU
TG506506
Kdm6b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 216850 |
|---|---|
| Synonyms | 1700064E03Rik; BC038313; Jmjd3; mKIAA0346 |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Format | Retroviral plasmids |
| Components | Kdm6b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 216850). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | BC075632, NM_001017426, NM_001017426.1, BC029201, BC038313, NM_001017426.2 |
| UniProt ID | Q5NCY0 |
| Summary | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (PubMed:21095589).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.