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Mfn2 Mouse shRNA Plasmid (Locus ID 170731)

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SKU
TG506067
Mfn2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 170731
Synonyms D630023P19Rik; Fzo
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mfn2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 170731). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC046503, NM_001285920, NM_001285921, NM_001285922, NM_001285923, NM_133201, NM_133201.1, NM_133201.2, NM_133201.3, NM_001285920.1, NM_001285921.1, NM_001285922.1, NM_001285923.1, NM_001355590, NM_001355591
UniProt ID Q80U63
Summary Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23921378, PubMed:23620051). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
Puri, Cheng, Lin et al
Nat Commun (2019) 10 (1), 3645 DOI: 10.1038/s41467-019-11636-5
AI Summary: In this study, OriGene's mouse Mfn2 shRNA constructs were used to selectively knock down Mfn2 expression, enabling the investigation of its role in mitochondrial dynamics and ER-mitochondrial contacts in neurons.
Snippet: A-PTPIP51 was provided by Christopher C.J. Miller (King’s College, UK). Mt-Keima was purchased from MBL (#AM-V0251HM) and verified by DNA sequencing. Mouse Mfn2 shRNA constructs were purchased from OriGene. The Mfn2 shRNA sequences are 5′-TCACCGTCAAGAAGGATAAGCGACACATG-3′ and 5′-AGCAGAGCCAAACTGCTCAGGAATAAAGC-3′. Cortical neuron culture and transfection Cortices were dissected from E18-19
FigureFigureFigure
Showing 1-1 of 1 papers.
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