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Adrbk1 Mouse shRNA Plasmid (Locus ID 110355)

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SKU
TG505928
Grk2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 110355
Synonyms Adrbk-1; Bark-1; beta ARK; betaARK1; GRK2
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Grk2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 110355). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC053922, NM_001290818, NM_130863, NM_130863.1, NM_130863.2, NM_001290818.1, BC003196, BC033272, BC038312
UniProt ID Q99MK8
Summary Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization
Fumagalli, Bonfanti, Daniele et al
Glia (2015)
Cited by 60
AI Summary: OriGene products contributed to this study by providing the GRK2 plasmid and the corresponding empty vector, which were used to manipulate GRK2 expression in oligodendrocyte precursor cells to investigate the molecular mechanisms underlying OPC maturation.
Snippet: according to the manufacture's instructions. In detail, OPCs were electroporated with 1 μg either of GRK2 plasmid (Origene) or the corresponding empty vector (OriGene, MD) with the O-017 program. After electroporation, cells were ... Cite SaveSaving
Showing 1-1 of 1 papers.
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