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Ehmt2 Mouse shRNA Plasmid (Locus ID 110147)

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SKU
TG505922
Ehmt2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 110147
Synonyms Bat8; D17Ertd710e; G9a; KMT1C; NG36
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Ehmt2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 110147). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001286573, NM_001286575, NM_145830, NM_147151, NM_147151.1, NM_147151.2, NM_145830.1, NM_145830.2, NM_001286575.1, NM_001286573.1, BC025539, BC051494, BC058357, BC096670, NM_001286575.2, NM_001286573.2, NM_147151.3, NM_145830.3
UniProt ID Q9Z148
Summary Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors
Yang, Kaur, Ong et al
Stem Cells International (2015) 2015
AI Summary: OriGene's gene-specific shRNA plasmids (GI540026 and GI540029) were used in this study to knock down G9a histone methyltransferase, enabling the investigation of its role in converting bone marrow mesenchymal stem cells to cardiac progenitors.
Snippet: Knockdown of G9a HMTase was carried out using gene-specific shRNA plasmids GI540026 and GI540029 (from OriGene), which are denoted in this study as shRNA676 and shRNA3291 in reference to the initial nucleotide position of the G9a sequence recognized ... Cite SaveSaving
Showing 1-1 of 1 papers.
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