Tdrd12 Mouse shRNA Plasmid (Locus ID 71981)
Specifications
| Product Data | |
| Locus ID | 71981 |
|---|---|
| Synonyms | 2410004F06Rik; 2410070K17Rik; ECAT8; EG434165; G1-476-14; repro23 |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | Tdrd12 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 71981). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | NM_001082581, NM_028034, NM_028034.1, NM_028034.2, NM_001368387 |
| UniProt ID | Q9CWU0 |
| Summary | Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:24067652). Involved in the secondary piRNAs metabolic process (PubMed:24067652). Acts via the PET complex, a multiprotein complex required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs (PubMed:26669262).UniProtKB/Swiss-Prot Function |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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