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Txnip Mouse shRNA Plasmid (Locus ID 56338)

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SKU
TG503152
Txnip - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 56338
Synonyms 1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Txnip - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 56338). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC011212, BC031850, NM_001009935, NM_023719, NM_023719.1, NM_023719.2, NM_001009935.1, NM_001009935.2
UniProt ID Q8BG60
Summary May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury
Genis, Dávila, Fernandez
F1000Research (2014) 3
Snippet: Dominant negative IGF-IR expression plasmid was kindly donated by D. Le Roith (Mt Sinai, New York, USA). Plasmids expressing shRNA for TXNIP1 were purchased from Origene (USA). Txnip1 plasmid was purchased from Thermo Scientific Open Biosystems (Waltham ... Cite SaveSaving
Showing 1-1 of 1 papers.
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