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Becn1 Mouse shRNA Plasmid (Locus ID 56208)

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SKU
TG503112
Becn1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 56208
Synonyms 4921513J16Rik; 5430417M23Rik; Atg6
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Becn1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 56208). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC005770, NM_019584, NM_019584.1, NM_019584.2, NM_019584.3, BC027738, NM_001359819, NM_001359820, NM_001359821, NM_019584.4
UniProt ID O88597
Summary Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693, PubMed:28445460). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function
Penna, Ballarò, Martinez-Cristobal et al
J. Mol. Biol. (2019) 431 (15), 2674-2686 DOI: 10.1016/j.jmb.2019.05.032
AI Summary: OriGene’s pGFP-V-RS plasmid carrying Becn1-targeting shRNA (GI357932) and a scrambled control plasmid were used to knock down Beclin-1 in C2C12 myoblasts, enabling the study of autophagy’s role in cancer-induced muscle wasting.
Snippet: Four distinct short hairpin RNA sequences targeting mouse Becn1 gene were tested in C2C12 myoblasts for knockdown efficiency. … The GI357932 sh-RNA showed the highest Beclin-1 knockdown efficiency (insert sequence: 5′-CACCATGCAGGTGAGCTTCGTGTGCCAGC-3′). …
Showing 1-1 of 1 papers.
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