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Ikzf1 Mouse shRNA Plasmid (Locus ID 22778)

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SKU
TG502473
Ikzf1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 22778
Synonyms 5832432G11Rik; hlk-1; I; Ikaros; LyF-; LyF-1; mKIAA4227; Zfpn; Zfpn1a1; Znfn1a1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Ikzf1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 22778). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001025597, NM_001301863, NM_001301865, NM_001301866, NM_001301868, NM_009578, NM_009578.1, NM_009578.2, NM_009578.3, NM_001025597.1, NM_001025597.2, NM_001301866.1, NM_001301865.1, NM_001301868.1, NM_001301863.1, BC138789
Summary The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Sep 2014
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia
Payne, Song, Ding et al
Int J Mol Sci (2020) 21 (5) DOI: 10.3390/ijms21051718
Cited by 7
AI Summary: OriGene’s pGP-V-RS shRNA plasmids were used in this study to knock down Ikaros (IKZF1) and CK2α (CSNK2A1) expression, enabling the authors to investigate their regulatory roles in Rab20 expression in B-cell acute lymphoblastic leukemia.
Snippet: e further cultured using the above conditions. 4.8. Ikaros and CK2 shRNA Knockdown Ikaros (IKZF1) and CSNK2A1 (CK2α) knockdown in Nalm6 and 697 cells was accomplished using pGP-V-RS shRNA plasmids (Origene) and a neon electroporation system (ThermoFisher Scientific) as described previously [115]. Knockdown of Ikaros and CK2α was confirmed using qRT-PCR. 4.9. Quantitative RT-PCR (qRT-PCR) RNA i
FigureFigureFigure
RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia
Han, Ma, Gu et al
J Cancer (2019) 10 (16), 3842-3850 DOI: 10.7150/jca.33989
AI Summary: OriGene's human IKZF1 shRNA constructs (pGFP-v-RS) were used to knock down IKZF1 expression in Nalm6 cells, enabling the study of IKZF1's role in regulating RAG1 expression in adult B-cell acute lymphoblastic leukemia.
Snippet: The humanIKZF1 shRNA constructs in the GFP vector (pGFP-v-RS) (Origene) was transiently transfected into Nalm6 cells using the Neon Transfection System (Invitrogen, USA). … IKZF1 Knockdown efficiency was confirmed by measurement of IKZF1 mRNA level with qPCR 14, 15, 19, 20. Primers: IKZF1-F: 5'-GGCGCGGTGCTCCTCCT-3', IKZF1-R: 5'-TCCGACACGCCCTACGACA-3'
FigureFigureFigure
Showing 1-2 of 2 papers.
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