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Satb1 Mouse shRNA Plasmid (Locus ID 20230)

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SKU
TG501973
Satb1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 20230
Synonyms 2610306G12Rik; AW413156
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Satb1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 20230). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC011132, NM_001163630, NM_001163631, NM_001163632, NM_009122, NM_001357636, NM_001357637, NM_001357638, NM_001357640, NM_009122.1, NM_009122.2, NM_001163632.1, NM_001163630.1, NM_001163631.1
UniProt ID Q60611
Summary Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons
Denaxa, Kalaitzidou, Garefalaki et al
Cell Rep (2012) 2 (5), 1351-62 DOI: 10.1016/j.celrep.2012.10.003
Cited by 112
AI Summary: OriGene’s pGFP-V-RS and pGFP-V-RS-scrShRNA plasmids were used as control and scrambled shRNA controls, respectively, to assess the requirement of Satb1 activity in cortical interneuron maturation by facilitating shRNA-mediated knockdown experiments.
Snippet: To examine the requirement of Satb1 activity for SST induction, we adopted a short-hairpin (sh)RNA approach to knock down endogenous Satb1 in interneuron precursors (Figure S1D). pGFP-V-RS (control), pGFP-V-RS-scrShRNA (scrambled small hairpin RNA [ShRNA] control
FigureFigureFigure
Showing 1-1 of 1 papers.
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