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Mif Mouse shRNA Plasmid (Locus ID 17319)

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SKU
TG501345
Mif - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 17319
Synonyms GIF; Glif
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mif - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 17319). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC024895, BC086928, BC100605, NM_010798, NM_010798.1, NM_010798.2, NM_010798.3
UniProt ID P34884
Summary Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Macrophage Migration Inhibitory Factor Regulates Akt Signaling in Hypoxic Culture to Modulate Senescence of Human Mesenchymal Stem Cells
Palumbo, Tsai, Li
Stem Cells Dev. (2013)
Cited by 49
AI Summary: OriGene products contributed to this study by providing the pCMV6-Entry vector containing the MIF gene for overexpression and the HuSH pGFP-V-RS control shRNA plasmid, which were used to manipulate MIF expression and investigate its role in regulating Akt signaling and senescence in human mesenchymal stem cells.
Snippet: To construct a plasmid for MIF overexpression, referred to as MIFover, the coding sequence of MIF gene of the pCMV6-Entry vector (Origene, Rockville, MD) was isolated by ... HuSH pGFP-V-RS (Origene). The control shRNA plasmid containing a non-specific scrambled ... Cite SaveSaving
Showing 1-1 of 1 papers.
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