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Meg3 Mouse shRNA Plasmid (Locus ID 17263)

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SKU
TG501330
Meg3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 17263
Synonyms Meg3, R74756, R75394, AI425946, AW108224, D12Bwg1266e, 2900016C05Rik, 3110050O07Rik, 6330408G06Rik
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Meg3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 17263). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC048191, NM_144513, NR_003633, NR_027651, NR_027652, NR_046475, NR_104450, NR_104451, BC024818, BC028971, BC051667, BC055835, BC094421
Summary This gene is paternally-imprinted and thus expressed predominantly from the maternal allele. It generates alternatively-spliced long non protein-coding RNAs that overlap with the microRNAs Mir770 and Mir1906-1. Transcripts from this gene function as negative regulators of growth and may be down-regulated in tumor cells. This gene is expressed in a reciprocal pattern from the nearby Dlk1 (delta-like 1 homolog) gene, which is paternally-expressed. Deletion of this locus disrupts imprinting in this genomic region and results in perinatal morbidity. provided by RefSeq, Dec 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity
Yen, Hsieh, Tsai et al
Elife (2018) 7 DOI: 10.7554/eLife.38080
AI Summary: OriGene’s Meg3 HuSH-29 shRNA plasmids (cat. No. TG501330) and non-effective scrambled control (TR20003) were used to stably knock down Meg3 lncRNA in embryonic stem cells, enabling the study of its role in motor neuron fate and identity.
Snippet: The Meg3 HuSH-29 shRNA plasmids (Origene, cat. … TG501330) and non-effective scrambled sequence (TR20003) were used to create stable knockdown lines of Meg3 within the Hb9::GFP ESCs. We used two different shRNA sequences to knockdown Meg3. …
FigureFigureFigure
Dlk1-Dio3 Locus-Derived LncRNAs Perpetuate Postmitotic Motor Neuron Cell Fate and Subtype Identity
Yen, Hsieh, Lu et al
bioRxiv (2018)
Snippet: The Meg3 HuSH-29 shRNA plasmids (Origene , cat. … TG501330) and noneffective scrambled sequence (TR20003) were used to create stable knockdown lines of Meg3 within the Hb9::GFP ESCs. We used two different shRNA sequences to knockdown Meg3. …
Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines
Mo, Wu, Tai et al
Stem Cell Res Ther (2015) 6 (1), 1 DOI: 10.1186/scrt535
Cited by 338
AI Summary: In this study, OriGene’s MEG3 shRNA (TG313367) and MEG3 siRNA (SR313367) products were used to knock down MEG3 expression in human embryonic stem cells, enabling the researchers to demonstrate that reduced MEG3 and DLK1-DIO3-derived non-coding RNAs correlate with impaired neural differentiation capacity.
FigureFigureFigure
Showing 1-3 of 3 papers.
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