OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

Mcl1 Mouse shRNA Plasmid (Locus ID 17210)

Be the first to review this product
SKU
TG501318
Mcl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

Frequently Bought Together (1)

TF81001 TurboFectin Transfection Reagent (1 mL in 1 vial)
1 ml in 1 vial
$530.00

Other products for "Mcl1 or NM_008562"

Specifications
Specifications
Product Data
Locus ID 17210
Synonyms AW556805; Mcl-1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Mcl1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 17210). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC003839, BC005427, BC021638, NM_008562, NM_008562.1, NM_008562.2, NM_008562.3
UniProt ID P97287
Summary Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model
Kuai, Wang, Wang et al
Sci Rep (2016) 6, 38219 DOI: 10.1038/srep38219
AI Summary: OriGene’s pCMV6-AC-MCL-1 plasmid was used to generate MCL-1 overexpressing H9c2 cells, enabling the study of MCL-1’s role in mediating the cardioprotective effects of HDAC inhibitors in hemorrhagic injury.
Snippet: Reagent (Invitrogen, Carlsbad, CA, USA). The MCL-1 over-expression-stable H9c2 cells were established by pCMV6-AC-MCL-1 plasmid (OriGene, Rockville, MD, USA) transfection and G418 screening. The gene knockdown or ... Cite SaveSaving
Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription
Thomas, Powell, Vergez et al
Blood (2013) 122 (5), 738-48 DOI: 10.1182/blood-2012-08-447441
Cited by 65
AI Summary: OriGene’s Mcl-1 expression plasmid was used to overexpress Mcl-1 in MV4;11 cells, enabling the authors to study the functional impact of Mcl-1 modulation on apoptosis in acute myeloid leukemia.
Snippet: MV4;11 cells were electroporated (250mV, 1000mF) with 10μg of an Mcl-1 expression plasmid (Origene) or a plasmid expressing myr-Akt. MV4;11 cells ... Mcl-1 is known to have a short half-life owing to its ubiquitination and targeting for degradation via the proteasome.
Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways
Oh, Erb, Hobisch et al
Endocr. Relat. Cancer (2012) 19 (3), 305-19 DOI: 10.1530/ERC-11-0298
Cited by 9
AI Summary: OriGene contributed to this study by providing the MCL-1 expression vector, which was used to investigate the role of MCL-1 in sorafenib-induced apoptosis in prostate cancer cells.
Snippet: Prostate cancer cells PC3, LNCaP, and 22Rv1 were obtained from ATCC (Rockville, MD, USA). Cell line authenticity was confirmed by short tandem repeat analysis. ... The MCL-1 expression vector was purchased from OriGene (Rockville, MD, USA). Proliferation assays.
FigureFigureFigure
Inhibition of NF-kappaB signaling by quinacrine is cytotoxic to human colon carcinoma cell lines and is synergistic in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or oxaliplatin
Jani, DeVecchio, Mazumdar et al
J Biol Chem (2010) 285 (25), 19162-72 DOI: 10.1074/jbc.M109.091645
AI Summary: In this paper, OriGene’s c-FLIP and Mcl-1 shRNA products were used to knock down these genes in colon carcinoma cell lines, demonstrating that their suppression sensitizes cells to TRAIL and oxaliplatin, thus highlighting the role of NF-kappaB target genes in drug resistance.
Showing 1-4 of 4 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products