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Jun Mouse shRNA Plasmid (Locus ID 16476)

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SKU
TG501139
Jun - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 16476
Synonyms AP-1; c-jun; Junc
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Jun - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 16476). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC002081, BC021888, BC094032, NM_010591, NM_010591.1, NM_010591.2, BC032086, BC055887
UniProt ID P05627
Summary Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGACGTCA-3' (PubMed:14707112). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling
Li, Volk, Zhang et al
Oncotarget (2017) 8 (5), 8420-8435 DOI: 10.18632/oncotarget.14220
Snippet: LCs were transduced with retrovirus-expressing shRNAs (Origene) specifically targeted to c-Jun (TG501139), JunB (TG516091), JunD (TG501140), and IL-1R (TG501076)
FigureFigureFigure
Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML
Volk, Li, Xin et al
J. Exp. Med. (2014)
Cited by 98
AI Summary: OriGene shRNA products targeting c-Jun (TG501139) and Mkps (1:TG514083; 3:TG514782; 5:TG513100) were used to specifically knock down these genes in leukemic cells, enabling the study of their roles in TNF-JNK-AP1 signaling and sensitivity to NF-κB inhibition in AML.
Snippet: LCs were transduced with retrovirus-expressing shRNAs (OriGene) specifically targeted to c-Jun (TG501139), or Mkps (1:TG514083;3:TG514782;5:TG513100)
Showing 1-2 of 2 papers.
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