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Irf1 Mouse shRNA Plasmid (Locus ID 16362)

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SKU
TG501105
Irf1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 16362
Synonyms AU020929; Irf-1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Irf1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 16362). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC003821, NM_001159393, NM_001159396, NM_008390, NM_001159396.1, NM_008390.1, NM_008390.2, NM_001159393.1
UniProt ID P15314
Summary Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity are: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Mediator kinase inhibition further activates super-enhancer-associated genes in AML
Pelish, Liau, Nitulescu et al
Nature (2015) 526 (7572), 273-6 DOI: 10.1038/nature14904
Cited by 417
AI Summary: OriGene products ETV6–Myc–Flag (SC118922), CDKN1b–Myc–Flag (SC117607), and FOSL2–Myc–Flag (SC110898) were used as expression constructs to study the effects of specific transcription factors on acute myeloid leukemia cell growth in the investigation of Mediator kinase inhibition and super-enhancer-associated gene activation.
Snippet: …Marto), Flag–IRF1 (PlasmID, HMS, HsCD00045286), Flag–IRF8 (PlasmID HMS, HsCD00438293), ETV6–Myc–Flag (Origene, SC118922), CDKN1b–Myc–Flag (Origene, SC117607), and FOSL2–Myc–Flag (Origene, SC110898) were cloned into the Tet-On inducible system pLVX-TRE3G-mCherry or pLVX-TRE3G-ZsGreen (Clontech), transformed into E. coli (Stellar Competent Cells, Clontech), packaged into lentiviral vectors and cotransduced with regulator vector pLVX-EF1a-Tet3G
Showing 1-1 of 1 papers.
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