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Clu Mouse shRNA Plasmid (Locus ID 12759)

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SKU
TG500381
Clu - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Other products for "Clu or NM_013492"

Specifications
Specifications
Product Data
Locus ID 12759
Synonyms A; AI893575; ApoJ; C; Cli; D14Ucl; D14Ucla3; Sg; Sgp; Sgp-2; Sgp2; SP-; SP-40; Sugp; Sugp-2
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Clu - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 12759). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC075668, NM_013492, NM_013492.1, NM_013492.2, NM_013492.3
UniProt ID Q06890
Summary The protein encoded by this gene is a secreted chaperone that can, under some stress conditions, also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. The encoded preproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric mature protein comprised of alpha and beta subunits. Mice lacking the encoded protein exhibit increased severity of autoimmune myocarditis, faster progression of the acute inflammation to myocardial scarring and decreased brain injury following neonatal hypoxic-ischemic injury. provided by RefSeq, Nov 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Lineage-specific restraint of pituitary gonadotroph cell adenoma growth
Chesnokova, Zonis, Zhou et al
PLoS ONE (2011) 6 (3), e17924 DOI: 10.1371/journal.pone.0017924
Cited by 50
AI Summary: OriGene products, specifically the siRNA targeting clusterin (siClu#2), were used in this study to suppress clusterin expression in murine pituitary gonadotroph cell lines, enabling the authors to demonstrate that reduced clusterin increases cell proliferation and decreases expression of cell cycle inhibitors p15 and p16.
Snippet: shown). Figure 8 (A,B) shows Western blots of representative experiments using siClu#2 where both clusterin protein forms were down-regulated, p15 and p16 levels were low, and pH 3 protein levels induced in both cell lines. In
FigureFigureFigure
Showing 1-1 of 1 papers.
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