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Apoe Mouse shRNA Plasmid (Locus ID 11816)

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SKU
TG500118
Apoe - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 11816
Synonyms A; AI255918; Apo-E
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Apoe - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 11816). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC028816, BC083351, NM_009696, NM_009696.1, NM_009696.2, NM_009696.3, NM_009696.4, BC044785
UniProt ID P08226
Summary This gene encodes a member of the apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related apolipoprotein C1, C2 and C4 genes. provided by RefSeq, Apr 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity
Lee, Yeo, Kim et al
Front Immunol (2019) 10, 1379 DOI: 10.3389/fimmu.2019.01379
AI Summary: OriGene products, specifically the mouse ApoE shRNA (TL502431) and mouse ApoE overexpression plasmid (MR200805), were used in this study to manipulate ApoE expression in lung cancer and B16F10 cells, enabling the authors to assess the role of ApoE in tumor growth and metastasis.
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Showing 1-1 of 1 papers.
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