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Ang Mouse shRNA Plasmid (Locus ID 11727)

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TG500091
Ang - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 11727
Synonyms AI385586; An; Ang1; Rn; Rnase5; Rnase5a
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components Ang - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 11727). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC055355, NM_001161731, NM_007447, NM_007447.1, NM_007447.2, NM_007447.3, NM_001161731.1, NM_001161731.2
UniProt ID P21570
Summary This gene encodes a member of the pancreatic ribonuclease A superfamily and is a potent inducer of neovascularization. The encoded protein is a secreted multifunctional tRNA-specific ribonuclease that promotes angiogenesis in response to angiogenetic stimuli such as hypoxia, mediates stress-induced translational repression by cleaving cellular tRNAs, stimulates cell proliferation by mediating rRNA transcription in prostate cancer cells, and is involved in neurite pathfinding. This gene resides in a cluster of highly related genes. It shares dual promoters and 5' exons with the ribonuclease, RNase A family 4 gene. Two alternatively spliced variants, with different 5' exons but the same coding exon, have been identified. Multiple pseudogenes have been found for this gene. provided by RefSeq, Jun 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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