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FOXO3 Human shRNA Plasmid Kit (Locus ID 2309)

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SKU
TG320359
FOXO3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 2309
Synonyms AF6q21; FKHRL1; FKHRL1P2; FOXO2; FOXO3A
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components FOXO3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2309). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001455, NM_201559, NM_201559.1, NM_201559.2, NM_001455.1, NM_001455.2, NM_001455.3, BC021224, BC021224.2, BC068552, BC020227, BC045800, NM_201559.3
UniProt ID O43524
Summary This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Role of TRPM2 in cell proliferation and susceptibility to oxidative stress
Chen, Zhang, Tong et al
Am. J. Physiol., Cell Physiol. (2013) 304 (6), C548-60 DOI: 10.1152/ajpcell.00069.2012
Cited by 68
AI Summary: OriGene products contributed to this study by providing the human GFP-FOXO3a overexpression construct and shRNAs targeting FOXO3a, which were used to manipulate FOXO3a levels and investigate its role in TRPM2-mediated cell proliferation and response to oxidative stress.
Snippet: Transient transfection. For overexpression of FOXO3a, human green fluorescent protein-FOXO3a construct was obtained from Origene Technologies (Rockville, MD). For depletion of FOXO3a, short-hairpin RNAs (shRNAs) targeted to FOXO3a were purchased from Origene.
Showing 1-1 of 1 papers.
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