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Prostaglandin E Synthase (PTGES) Human shRNA Plasmid Kit (Locus ID 9536)

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SKU
TG318942
PTGES - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Other products for "Prostaglandin E Synthase or NM_004878"

Specifications
Specifications
Product Data
Locus ID 9536
Synonyms MGST-IV; MGST1-L1; MGST1L1; MPGES; mPGES-1; PGES; PIG12; PP102; PP1294; TP53I12
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components PTGES - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 9536). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_004878, NM_198797, NM_004878.1, NM_004878.2, NM_004878.3, NM_004878.4, BC008280, BC008280.1, BC018201, BM550187, NM_004878.5
UniProt ID O14684
Summary The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1
Imbert, Montfort, Fraisse et al
Nat Commun (2020) 11 (1), 437 DOI: 10.1038/s41467-019-14218-7
Cited by 124
AI Summary: OriGene's non-effective 29-mer scrambled shRNA (shCtrl(P)) was used as a control in experiments involving Ptges gene silencing to assess the role of SK1 in melanoma resistance to immune checkpoint inhibitors.
Snippet: Ctrl) plasmid (pLK01, Addgene). In other experiments, Yumm cells were transfected with a Ptges shRNA (shPtges) construct in a retroviral GFP vector or non-effective 29-mer scrambled shRNA (shCtrl(P);Origene). Cells were transfected using Lipofectamine 2000 reagent (Invitrogen). Transfected shSK1 and shCtrl cells were selected with puromycin and G418. shPtges and shCtrl(P) cells were selected only;...
FigureFigureFigure
Showing 1-1 of 1 papers.
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