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MGMT Human shRNA Plasmid Kit (Locus ID 4255)

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SKU
TG316615
MGMT - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4255
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MGMT - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4255). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_002412, NM_002412.1, NM_002412.2, NM_002412.3, NM_002412.4, BC000824, BC000824.1, NM_002412.5
UniProt ID P16455
Summary Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

O6-Methylguanine-DNA methyltransferase is a novel negative effector of invasion in glioblastoma multiforme
Chahal, Abdulkarim, Xu et al
Mol Cancer Ther (2012) 11 (11), 2440-50 DOI: 10.1158/1535-7163.MCT-11-0977
AI Summary: In this study, OriGene products—including the MGMT expression plasmid (RC204747) and MGMT shRNA plasmids (TG313073, TG313074)—were used to modulate MGMT levels in glioblastoma cell lines, enabling the authors to investigate the role of MGMT in regulating tumor cell invasion.
Showing 1-1 of 1 papers.
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