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BMI1 Human shRNA Plasmid Kit (Locus ID 648)

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SKU
TG314462
BMI1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 648
Synonyms flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components BMI1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 648). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_005180, NM_005180.1, NM_005180.2, NM_005180.3, NM_005180.4, NM_005180.5, NM_005180.6, NM_005180.7, NM_005180.8, BC011652, BC011652.2, NM_005180.9
UniProt ID P35226
Summary This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Polycomb protein BMI1 regulates osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells downstream of GSK3
Becker, Potapenko, Niklaus et al
Stem Cells Dev. (2016)
Cited by 22
AI Summary: In this study, the HuSH shRNA vector from OriGene was used to knock down BMI1 expression, enabling the authors to investigate BMI1's role in the osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells.
Snippet: from the pPuroGAL4-DBD-mBmi-vector [36] (kindly provided by Maarten van Lohuizen) into the pCFG5 IEGZ (pEGZ) backbone. The HuSH shRNA vector (ORIGENE) was used for the shRNA-targeted KD of BMI1. Four different shRNA sequences were pre- ... Cite SaveSaving
Showing 1-1 of 1 papers.
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