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BRCA1 Human shRNA Plasmid Kit (Locus ID 672)

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SKU
TG314440
BRCA1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 672
Synonyms BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components BRCA1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 672). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_007294, NM_007295, NM_007296, NM_007297, NM_007298, NM_007299, NM_007300, NM_007301, NM_007302, NM_007303, NM_007304, NM_007305, NM_007306, NR_027676, NM_007299.1, NM_007299.2, NM_007299.3, NM_007294.1, NM_007294.2, NM_007294.3, NM_007297.1, NM_007297.2, NM_007297.3, NM_007300.1, NM_007300.2, NM_007300.3, NM_007298.1, NM_007298.2, NM_007298.3, NM_007302.2, NM_007304.2, NM_007295.2, NM_007303.2, NM_007301.2, BC115037, BC012577, BC030969, BC038947, BC046142, BC062429, BC072418, BC085615, BC106745, BC106746, BC114511, BC114562, NM_007297.4, NM_007299.4, NM_007294.4
UniProt ID P38398
Summary This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. provided by RefSeq, May 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

BRCA1 and NORE1A Form a Her2/Ras Regulated Tumor Suppressor Complex Modulating Senescence
Nelson, Jigo, Clark
Cancers (Basel) (2023) 15 (16) DOI: 10.3390/cancers15164133
Cited by 3
AI Summary: OriGene contributed to this study by providing shRNAs for human BRCA1 (SKU: TG314440), which were used to generate stable cell lines with suppressed BRCA1 expression to investigate its role in tumor suppression and senescence.
Snippet: shRNAs for human BRCA1 were obtained from Origene (SKU: TG314440), and stable transfected cell lines were obtained after selection with puromycin dihydrochloride ( Save Cached
FigureFigureFigure
Showing 1-1 of 1 papers.
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