ERG Human shRNA Plasmid Kit (Locus ID 2078)
SKU
TG313172
ERG - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 2078 |
|---|---|
| Synonyms | erg-3; p55 |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | ERG - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2078). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | NM_001136154, NM_001136155, NM_001243428, NM_001243429, NM_001243432, NM_001291391, NM_004449, NM_182918, NR_111949, NM_001331025, NM_182918.1, NM_182918.2, NM_182918.3, NM_004449.1, NM_004449.2, NM_004449.3, NM_004449.4, NM_001136154.1, NM_001136155.1, NM_001243432.1, NM_001243432.2, NM_001243429.1, NM_001243428.1, NM_001291391.1, BC040168, BC040168.1, NM_001243433 |
| UniProt ID | P11308 |
| Summary | This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. provided by RefSeq, Apr 2014 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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