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FAIM2 Human shRNA Plasmid Kit (Locus ID 23017)

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SKU
TG313099
FAIM2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 23017
Synonyms LFG; LFG2; NGP35; NMP35; TMBIM2
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components FAIM2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 23017). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_012306, NM_012306.1, NM_012306.2, NM_012306.3, BC000051, BC000051.2, NM_012306.4
UniProt ID Q9BWQ8
Summary Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple-negative breast cancer cells
Radin, Lippa, Patel et al
Biomed. Pharmacother. (2016) 77, 161-6 DOI: 10.1016/j.biopha.2015.12.022
Cited by 37
AI Summary: OriGene's shRNA for Lifeguard (LFG) protein (#TG313099) was used to stably knock down Lifeguard expression in MDA-MB-231 cells, enabling the study of its role in Fas-mediated apoptosis and cisplatin resistance in triple-negative breast cancer.
Snippet: The same growth and maintenance was performed for Dermal Fibroblasts (ATCC, #PCS-201-012). 2.2. Stable transfection. shRNA for Lifeguard (LFG) protein (Origene, Rockville, MD, #TG313099) was obtained and the manufacturer's transfection protocol was followed ... Cite SaveSaving
Showing 1-1 of 1 papers.
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