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GRB7 Human shRNA Plasmid Kit (Locus ID 2886)

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SKU
TG312621
GRB7 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 2886
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components GRB7 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2886). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001030002, NM_001242442, NM_001242443, NM_001330207, NM_005310, NM_001030002.1, NM_001030002.2, NM_005310.1, NM_005310.2, NM_005310.3, NM_001242443.1, NM_001242442.1, BC006535, NM_005310.5
UniProt ID Q14451
Summary The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. provided by RefSeq, Jun 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Targeting GRB7/ERK/FOXM1 signaling pathway impairs aggressiveness of ovarian cancer cells
Chan, Hui, Cai et al
PLoS ONE (2012) 7 (12), e52578 DOI: 10.1371/journal.pone.0052578
Cited by 53
AI Summary: OriGene’s 29-mer scrambled shRNA (TR30013) was used as a negative control in experiments investigating the role of the GRB7/ERK/FOXM1 signaling pathway in ovarian cancer aggressiveness.
Snippet: USA). The non-effective 29-mer scrambled shRNA (TR30013) (OriGene Technologies) was used as a negative control. ... pathogenesis. Therefore, targeting this signaling cascade may achieve a good outcome when treating this type of disease.
FigureFigureFigure
Showing 1-1 of 1 papers.
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